The Diabetes Prevention Program (DPP), funded by the ational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)N and conducted at 27 centers nationwide, was a landmark trial to show that lifestyle changes or metformin can effectively delay diabetes in a diverse population of American adults with overweight or obesity who are at high risk of diabetes in the short term and long term compared to placebo. The Diabetes Prevention Program Outcomes Study (DPPOS) began in 2002 and is now in its fourth phase. DPPOS Phase 4 (DPPOS-4) focuses on the course of brain aging and development of Alzheimer’s disease and related disorders among individuals with pre-diabetes or diabetes.
https://dppos.bsc.gwu.edu/web/dppos/dpposPublications:
Shapiro Allison LB, Tjaden Ashley H, Edelstein Sharon L, Kahn Steven E, Srikanthan Preethi, Knowler William C, Venditti Elizabeth M, Golden Sherita H, Carmichael Owen, Luchsinger Jose A, DPP Research Group. The association of insulin responses and insulin sensitivity with cognition in adults with pre-diabetes: The Diabetes Prevention Program Outcomes Study. J Diabetes Complications. 2024;38(6):108764
Grants:
U19 AG078558
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Role:
Site PI
