We have been collecting brain MRI and brain PET scans from participants in the Bogalusa Heart Study since 2020. Our data suggests that higher fasting blood glucose during childhood is associated with negative effects on the brain decades later, in middle age. We have also found hints that brain functional connectivity in middle may be associated with recognized indicators of heart health, including blood pressure and hemoglobin A1C. Finally, we have found race and sex differences in cognitive function and brain health measures in a number of different settings. Together, our results to date suggest that cardiovascular health throughout the lifespan, along with demographic and socioeconomic factors, have an influence on brain health in a Deep Southern community setting.
https://bogalusaheartstudy.org/Publications:
Carmichael O, Stuchlik P, Pillai S, Biessels GJ, Dhullipudi R, Madden-Rusnak A, Martin S, Hsia DS, Fonseca V, Bazzano L. High-normal adolescent fasting plasma glucose is associated with poorer midlife brain health: Bogalusa heart study. J Clin Endocrinol Metab. 2019;104:4492-4500. PMCID: PMC6736207. PMID: 31058974.
De Anda-Duran I, Alonso CF, Libon DJ, Carmichael OT, Kolachalama VB, Suglia SF, Au R, Bazzano LA. Carotid intima-media thickness and midlife cognitive function: Impact of race and social disparities in the Bogalusa heart study. Neurology. 2022;98(18):e1828-e36. PMCID: PMC9109147. PMID: 35228334.
Chuang KC, Ramakrishnapillai S, Madden K, St Amant J, McKlveen K, Gwizdala K, Dhullipudi R, Bazzano L, Carmichael O. Brain effective connectivity and functional connectivity as markers of lifespan vascular exposures in middle-aged adults: The Bogalusa Heart Study. Front Aging Neurosci. 2023;15:1110434. PMID: 36998317. PMCID: PMC10043334.
De Anda-Duran I, Kolachalama VB, Carmichael OT, Hwang PH, Fernandez C, Au R, Bazzano LA, Libon DJ. Midlife Neuropsychological Profiles and Associated Vascular Risk: The Bogalusa Heart Study. J Alzheimers Dis. 2023;94(1):101-13. PMID: 37212094. PMCID: PMC10443183.
Gwizdala KL, Bazzano LA, Newton, Jr. RL, Carmichael OT. Race and sex differences in the association between lifespan glycemic status and midlife cognitive function: The Bogalusa Heart Study. Frontiers in Public Health, section Aging and Public Health. 2023;11:1200415. PMCID: PMC10684774. PMID: 38035298.
Sun, X., W. Chen, A. C. Razavi, M. Shi, Y. Pan, C. Li, M. Argos, B. T. Layden, M. L. Daviglus, J. He, O. T. Carmichael, L. A. Bazzano, and T. N. Kelly. "Associations of Epigenetic Age Acceleration with Cvd Risks across the Lifespan: The Bogalusa Heart Study." JACC Basic Transl Sci 9, no. 5 (May 2024): 577-90.
Carmichael O, Stuchlik P, Pillai S, Biessels GJ, Dhullipudi R, Madden-Rusnak A, Martin S, Hsia DS, Fonseca V, Bazzano L. High-normal adolescent fasting plasma glucose is associated with poorer midlife brain health: Bogalusa heart study. J Clin Endocrinol Metab. 2019;104:4492-4500. PMCID: PMC6736207. PMID: 31058974.
De Anda-Duran I, Alonso CF, Libon DJ, Carmichael OT, Kolachalama VB, Suglia SF, Au R, Bazzano LA. Carotid intima-media thickness and midlife cognitive function: Impact of race and social disparities in the Bogalusa heart study. Neurology. 2022;98(18):e1828-e36. PMCID: PMC9109147. PMID: 35228334.
Chuang KC, Ramakrishnapillai S, Madden K, St Amant J, McKlveen K, Gwizdala K, Dhullipudi R, Bazzano L, Carmichael O. Brain effective connectivity and functional connectivity as markers of lifespan vascular exposures in middle-aged adults: The Bogalusa Heart Study. Front Aging Neurosci. 2023;15:1110434. PMID: 36998317. PMCID: PMC10043334.
De Anda-Duran I, Kolachalama VB, Carmichael OT, Hwang PH, Fernandez C, Au R, Bazzano LA, Libon DJ. Midlife Neuropsychological Profiles and Associated Vascular Risk: The Bogalusa Heart Study. J Alzheimers Dis. 2023;94(1):101-13. PMID: 37212094. PMCID: PMC10443183.
Gwizdala KL, Bazzano LA, Newton, Jr. RL, Carmichael OT. Race and sex differences in the association between lifespan glycemic status and midlife cognitive function: The Bogalusa Heart Study. Frontiers in Public Health, section Aging and Public Health. 2023;11:1200415. PMCID: PMC10684774. PMID: 38035298.
BHS Grants:
R01 AG077497
I3C DECADE: Disparities and Equity in Childhood Cardiovascular Exposures and Alzheimer's Dementia
Role: PI (with L Bazzano and E Urbina)
RF1 AG075769 NIH/NIA
Reproductive history and later-life brain health: The Bogalusa Heart Study
Role: PI (with E Harville and L Bazzano)
R01 AG077000 NIH (NIA)
Early Life Cardiovascular Disease Risk Factors, Epigenetic Age Acceleration, and Alzheimer's Disease Related Brain Health
Role: PI (with Tanika Kelly and Lydia Bazzano)
RF1 AG041200 Tulane/NIA
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart Study
Role: PI (with Lydia Bazzano)
R01 AG062309 Tulane/NIA
Early Life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart Study
Role: PI (with Lydia Bazzano)
LaCATS Pilot Project
Lifespan Cardiovascular Exposures and Risk of Brain Injury in the Bogalusa Heart Study
Role: Co-Investigator
