Jianping Ye, Principal Investigator

  YeJ@pbrc.edu

  Faculty Bio

Dr. Ye is a Professor of Molecular Biology at the Pennington Biomedical Research Center in the Louisiana State University System. He is the director of Gene Regulation laboratory. He finished his medical school training in China in 1989. He has a broad research experience in life science that includes immune tolerance, bone marrow transplantation, herbal medicines, T-cell function, breast cancer, prostate cancer, lung cancer, heavy metal toxicity, obesity and type 2 diabetes.  He was trained as an immunologist in graduate school and in postdoctoral stage.

His major research interests include signal transduction and gene transcription of cytokines. Now, his study is focused on the cellular and molecular mechanism of insulin resistance, a pathogenic status that leads to type 2 diabetes. Inflammation is the major model in his research in previous cancer research and in current diabetes research. He is investigating herbal medicine in the treatment of type 2 diabetes. He has more than 80 peer-reviewed publications with more than 1500 times of citation. His current research is supported by NIH and ADA.         

Xin Ye joined the Antioxidant and Gene Regulation Lab in 2009 from China. She received her B.S. in accounting from the Henan LiGong University.  In the lab, her expertises includ Western, cell culture, fatty acid metabolism, genotyping and breeding of transgenic mice. 

Gang Yu, Research Laboratory Manager

YuG@pbrc.edu

 

Gang was a research associate in the lab during 2005-2006. Gang Yu received his M.S. in Biochemistry from Louisiana State University in 1996.  His lab duties included lab safety, equipment repair, and research in Transgenic mice.  His research interests are cloning, CHIP assay, and Transgenic mice.  Gang left the lab to join the Stem Cell Biology laboratory, which is under the direction of Dr. Jeff Gimble.

Wei Tseng, Research Associate

 

Wei was a resarch associate in the lab during 2004-2005. Wei Tseng received her B.S. from Louisiana State University in Microbiology with a minor in Chemistry.  Her lab duties included assisting the researchers, performing animal research, and taking care of the lab by doing things such as cleaning, organizing, and ordering supplies. Her main research interest centers around animal research.  Wei left the lab on July 14, 2006 to move to Cleveland, Ohio where she will attend the Ohio College of Podiatric Medicine.

Carrie Elks, Graduate Assistant

Carrie was a student in the lab for few month in 2005. Carrie Elks came to the Antioxidant and Gene Regulation Lab as a graduate assistant at Louisiana State University to perform research for her Ph.D. dissertation.  Carrie received her B.S. from Louisiana State University with Upper Division Honors in Dietetics in 2001.  On May 19, 2006 she received her M.S. from Louisiana State University in Human Ecology with a concentration in Human Nutrition and Food.  Her lab duties included assisting the researchers, performing animal research, and taking care of the lab (cleaning, organizing, ordering).  Carrie's research interest is the effects of post-translational methylation on various proteins in the insulin signaling pathway, and how these effects may play a role in insulin resistance.  She left the lab on July 12, 2006 to join the LSU Veterinary School graduate program to do Nephrology research.

Jin-hua Yan, Research Associate Technician

 

Jin-hua was an exchange Ph.D. student during 2005-2006. Jin-hua Yan joined the Antioxidant and Gene Regulation Lab in April 2005.  Originally from Jiang Xi province, P. R. China, Jin-hua received her M.D. from Jiang Xi Medical College in 2001.  She did her Ph.D. resarch in the lab and obtained Ph.D. degree at the Sun Yat-Sen University in 2007.  In the lab she worked with cell cultures, Western blotting, gel shifts, and reporter assays. She studied hepatic gluconeogenesis in hepatocytes. Her observation suggests that NF-kB inhibits hepatic gluconeogenesis by suppressing PEPCK gene transcription. The mechanism is activation of HDAC3 by NF-kB, and CREB suppression by HDAC3 in the PEPCK gene promoter. She left the lab on July 12, 2006 to return to China to finished her Ph.D.

Yanning Wang, Master Student

Yanning.Wang@pbrc.edu

 

Yanning Wang was a master student during 2007-2009 in the division of human nutrition and food in the school of human ecology, LSU. Grown up in Zhenjiang city, Jiansu province, she received her M.D. degree in the Jiangsu University in 2005. Then, she was directly admitted into the Fudan University in Shanghai to study for a masters degree for two years. She joined the Antioxidant and Gene Regulation Lab in Jan, 2007 before she received her masters degree. Her research interest focuses on the mechanism by which FFA induces insulin resistance. She was studying the relationship between FFA and inflammatory in obesity. In her spare time, Yanning loves traveling, shopping and listening music.

Tianyi Tang, Master Student

Tianyi.Tang@pbrc.edu

 

Tianyi Tang was a masters student in the lab during 2007-2009. She grew up in the Guangzhou City, P. R. China, received her M.D. at the Sun Yat-sen University in 2003. In the spring of 2007, Tianyi began her masters study in the School of Human Ecology in the Louisiana State University. Her study is focused on Nutrition and obesity. She did metabolic phenotyping of aP2-p65 mice. Her observation suggests that over expression of NF-kB p65 subunit in the adipocytes and macrophages leads to chronic inflammation in adipose tissue. Inflammatory cytokines were also elevated in the circulation. These are responsible for an increase in energy expenditure and a mild lipodystrophy in the mice. The energy expenditure protects the mice from dietary obesity and insulin resistance.

Hanjie Zhang , Master Student

Hanjie.Zhang@pbrc.edu

 

Hanjie was a master student in the lab during 2007-2008. Hanjie Zhang joined to the Antioxidant and Gene Regulation Lab from Shanghai, China. She received her B.S. degree (2003) from the China Pharmaceutical University, Nanjing, China and M.S. degree (2006) from the Shanghai Jiao Tong University, Shanghai, China. Her previous research was mainly focused on the Chinese Herbal Medicine. She joined the lab in Jan. 2007. She transfered to Dr. Roy Martin's lab in 2008.