Antioxidant & Gene Regulation Laboratory

Antioxidant and Gene Regulation Lab

Pennington Biomedical Research Center (PBRC)

Louisiana State University System (LSU)

Our research is conducted to understand the cellular and molecular mechanisms of insulin resistance. Three mouse model systems are used in our study: Transgenic mice of NF-kB, pharmacological study of Berberine and sodium butyrate and surgical model of RYGB. The transgenic studies suggest that adipose tissue expansion induces a local hypoxia response that triggers the chronic inflammation in obesity. The inflammation stimulates energy expenditure in favor of restoring the energy balance in the body. These conclusions suggest that the chronic inflammation is a compensatory response in obesity with a protective role. Benefits of the inflammatory response are executed through several coordinated events including inhibition of adipogenesis, promotion of adipocyte lipolysis, stimulation of lipid mobilization, and induction of adipose angiogenesis. This view suggests that the inflammation is not induced to impair systemic insulin sensitivity in the obese condition. Instead, it is generated to protect the body from energy surplus. This interpretation of biological activity of the inflammation is different from the classical view that considers the inflammation as a pure risk factor of insulin sensitivity. Anti-inflammatory therapies have been tested in many clinical trials for improvement of insulin sensitivity in type 2 diabetic patients for 20 years. The efficacy was disappointed and the reason was unknown. Our view provides an answer to the poor efficacy. The view also explains the weight gain from the anti-inflammatory therapies in patients. The pharmacological and surgical models provide consistent results that a negative energy balance is a promising strategy in the treatment of insulin resistance. The three model systems suggest that energy surplus in cells is responsible for systemic insulin resistance. The signaling pathway of energy surplus-induced insulin resistance is under investigation.

Dr. Jianping Ye, M.D.

Professor of Molecular Biology

PBRC/LSU

6400 Perkins Road

Baton Rouge, LA  70808-4124

Office Phone: (225) 763-3163

Fax: (225) 763-0274

E-Mail: YeJ@pbrc.edu

 

 

 

Last Updated On: Thursday, June 10, 2015