Year 2008 full papers:

1. Pan W, Barron M, Hsuchou H, Tu H, Kastin AJ. Increased leptin permeation across the blood-brain barrier after chronic alcohol ingestion. Neuropsychopharmacology, 33: 859 - 66, 2008 [full text]

2. Tu H, Kastin AJ, Hsuchou H, Pan W. Soluble receptor inhibits leptin transport. Journal of Cell Physiology, 214:301-5, 2008 [full text]

2. Pan W, Hsuchou H, Tu H, Kastin AJ. Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology, 149: 877 - 885, 2008 [full text]

3. Pan W, Kastin AJ. Urocortin and the Brain. Progress in Neurobiology, 84: 148 - 156, 2008 [full text]

4. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, Kastin AJ. Astrocyte ObR and leptin transport in adult-onset obese mice. Endocrinology, 149:2798-806, 2008 [full text]

5. Pan W, Hsuchou H, Yu C, Kastin AJ. Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS. Journal of Neurochemistry, 106: 313-9, 2008 [full text]

6. Gupta AK, Greenway FL, Cornelissen G, Pan W, Halberg F. Prediabetes is associated with abnormal circadian blood pressure variability. Journal of Clinical Hypertension, 22:627-33, 2008

7. Wang QP, Guan JL, Pan W, Kastin AJ, Shioda S. A diffusion barrier between the area postrema and nucleus tractus solitarius. Neurochemical Research, 33: 2035-43, 2008

8. Pan W, Yu C, Hsuchou H, Zhang Y, Kastin AJ. Neuroinflammation facilitates LIF entry into brain: role of TNF. Americal Journal of Physiology, 294: C1436-42, 2008 [full text]

9. Kastin AJ, Pan W. Blood-brain barrier and feeding: Regulatory roles of saturable transport systems for ingestive peptides. Current Pharmaceutical Design, 14: 1615-9, 2008 [full text]

10. Pan W, Kastin AJ. Cytokine transport across the injured blood-spinal cord barrier. Current Pharmaceutical Design, 14: 1620-4, 2008 [full text]

11. Yu C, Argyropoulos G, Zhang Y, Kastin AJ, Hsuchou H, Pan W. Neuroinflammation activates Mdr1b efflux transport through NFκB: promoter analysis in BBB endothelia. Cellular Physiology & Biochemistry, 22: 756-66, 2008 [full text]

Year 2007 full papers:

1. Yu C, Kastin AJ, Ding Y, Pan W. Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke. Experimental Neurology, 203: 116 - 22, 2007 [full text]

2. Tu H, Kastin AJ, Pan W. CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Molecular Endocrinology, 21:700-11, 2007 [full text]

3. Pan W, Kastin AJ. Mahogany, blood-brain barrier, and fat mass surge in Avy mice. International Journal of Obesity, 31: 1030 - 1032. 2007 [full text]

4. Tu H, Pan W, Feucht L, Kastin AJ. Convergent trafficking pattern of leptin after endocytosis mediated by ObRa - ObRd. Journal of Cell Physiology, 212:215-222, 2007 [full text]

5. Pan W, Kastin AJ, Daniel J, Yu C, Baryshnikova LM, von Bartheld CS. TNFα trafficking in cerebral vascular endothelial cells. Journal of Neuroimmunology, 185: 47 - 56, 2007 [full text]

6. Yu C, Kastin AJ, Tu H, Pan W. Opposing effects of proteasomes and lysosomes on LIFR: modulation by TNF. Journal of Molecular Neuroscience, 32: 80 - 89, 2007 [full text]

7. Pan W, Tu H, Yu C, Hsuchou H, Yang Y, Kastin AJ. Differential role of TNF receptors in cellular trafficking of intact TNF. Cellular Physiology and Biochemistry, 20: 559 - 568, 2007 [full text]

8. Tu H, Kastin AJ, Bjorbaek C, Pan W. Urocortin trafficking in cerebral microvessel endothelial cells. Journal of Molecular Neuroscience, 31:171-82, 2007 [full text]

9. Yu C, Kastin AJ, Pan W. TNF reduces LIF endocytosis despite increasing NFkB-mediated gp130 expression. Journal of Cell Physiology, 213: 161 - 166, 2007 [full text]

10. Pan W, Kastin AJ. Adipokines and the blood-brain barrier. Peptides, 28: 1317 - 1330, 2007 [full text]

11. Pan W, Kastin AJ. Tumor necrosis factor and stroke: role of the blood-brain barrier. Progress in Neuorobiology, 83: 363 - 374, 2007 [full text]

12. Yu C, Kastin AJ, Tu H, Waters S, Pan W. TNF activates P-glycoprotein in cerebral microvascular endothelial cells. Cellular Physiology and Biochemistry, 20: 853 - 858, 2007 [full text]

13. Pan W, Tu H, Hsuchou H, Daniel J, Kastin AJ. Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity. Journal of Molecular Neuroscience, 33:232-8, 2007 [in press full text]

14. Pan W, Hsuchou H, Kastin AJ. Nesfatin-1 crosses the blood-brain barrier without saturation. Peptides, 28:2223-8, 2007 [full text]

15. Hsuchou H, Pan W, Kastin AJ. The fasting polypeptide FGF21 can enter brain from blood. Peptides, 28: 2382 - 2386, 2007 [full text]

16. Pan W, Kastin AJ. From MIF-1 to endomorphin: The Tyr-MIF-1 family of peptides. Peptides, 28: 2411 - 2434, 2007 [full text]

Year 2007 book chapters:

17. Pan W, Kastin AJ. In vivo techniques quantifying blood-brain barrier permeability to small proteins in mice. In: Neuropeptide techniques. Gozes I ed., Humana Press, in press [full text]

18. Pan W, Kastin AJ. Ingestive peptides interact with the blood-brain barrier. In: Nutrition and brain disorders. Prasad C ed., in book series: Nutrition, Brain and Behavior, Harwood Academic Publishers of Amsterdam, in press

Year 2006 full papers:

1. Pan W, Ding Y, Yu Y, Ohtaki H, Nakamachi T, Kastin AJ. Stroke upregulates TNFα transport across the blood-brain barrier. Experimental Neurology, 198: 222 - 233, 2006 [full text]

2. Pan W, Tu H, Kastin AJ. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides, 27: 911 - 916, 2006 [full text]

3. Kastin AJ, Pan W. Editorial: Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity? Endocrinology, 147: 2086 - 2087, 2006 [full text]

4. Pan W, Cain C, Yu Y, Kastin AJ. Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury. Journal of Neuroimmunology, 174: 119 - 125, 2006 [full text]

5. Yu Y, Kastin AJ, Pan W. Reciprocal interactions of insulin and IGF-1 in receptor-mediated transport across the BBB. Endocrinology, 147: 2611 - 2615, 2006 [full text]

6. Pan W, Yu Y, Yemane R, Cain C, Yu C, Kastin AJ. Permeation of hepatocyte growth factor across the blood-brain barrier. Experimental Neurology, 201: 99 - 104, 2006 [full text]

Year 2006 book chapters:

7. Pan W, Yu, Nyberg F, Kastin AJ. Growth hormone, insulin, and insulin-like growth factor-I: do they interact at the blood-brain barrier? PP75 - 79. In: The Somatotrophic axis in brain function. F Nyberg ed., Elsevier Academic Press, 2006 [full text]

8. Pan W, Xiang S, Tu H, Kastin AJ. Cytokines interact with the blood-brain barrier. PP247 - 264. In Blood-brain interface: From ontogeny to artificial barriers. R. Dermietzel, D.C. Spray, and M. Nedergaard ed., Wiley-VCH, 2006 [full text]

9. Pan W. Permeability of the blood-brain barrier to neurotrophic peptides. Chapter 200, pp1435 - 1441. In: Handbook of Biologically Active Peptides, Kastin AJ ed., Elsevier, 2006 [full text]

10. Halberg F, Cornelissen G, et al., Peptide Chronomics. Chapter 213, pp1529 - 1564. In: Handbook of Biologically Active Peptides, Kastin AJ ed., Elsevier, 2006 [full text]

11. Preface of The Book. Kastin AJ, 2006 [full text]

Year 2005 full papers:

1. Ding Y, Kastin AJ, Pan W. Neural plasticity after spinal cord injury. Current Pharmaceutical Design, 11: 1441-50, 2005 [full text]

2. Xiang S, Pan W, Kastin AJ. Strategies to create a regenerating environment for the injured spinal cord. Current Pharmaceutical Design, 1267-77, 2005 [full text]

3. Kastin AJ, Pan W. Targeting neurite growth inhibitors to induce CNS regeneration. Current Pharmaceutical Design, 11: 1247-53, 2005 [full text]

4. Pan W. Spinal cord injury and repair. preface for Current Pharmaceutical Design, 11(10) and 11(11), 2005 [full text 1] [full text 2]

5. Pan W, Yu Y, Nyberg F, Couraud PO, Kastin AJ. Permeation of growth hormone across the blood-brain barrier. Endocrinology, 146: 4898-904, 2005 [full text]

6. Pan W, Kastin AJ, Yu Y, Cain C, Fairburn T, Stütz AM, Morrison C, Argyropoulos G. Selective tissue uptake of AgRP83-131 and its modulation by fasting. Endocrinology, 146:5533-5539, 2005. [full text]

7. Jozsa R, Halberg F, Cornélissen G, Zeman M, Kazsaki J, Csernus V, Katinas GS, Wendt HW, Schwartzkopff O, Stebelova K, Dulkova K, Chibisov SM, Engebretson M, Pan W,  Bubenik GA, Nagy G, Herold M, Hardeland R, Hüther G, Pöggeler B, Tarquini R, Perfetto F, Salti R, Olah A, Csokas N, Delmore P, Otsuka K, Bakken EE, Allen J, Amory-Mazaudin C. Chronomics, neuroendocrine feedsidewards and the recording and consulting of nowcasts—forecasts of geomagnetics. Biomedicine & Pharmocotherapy, 59: S24 – S30.

8. Jozsa R, Olah A, Cornélissen G, Csernus V, Otsuka K, Zeman M, Nagy G, Kazsaki J, Stebelova K, Pan W , Herold M, Halberg F. Circadian and extracircadian exploration during daytime hours of circulating corticosterone and other endocrine chronomes. Biomedicine & Pharmocotherapy, 59: S109 - S116, 2005. [full text]

9. Stebelova K, Zeman M, Cornélissen G, Bubenik G, Jozsa R, Hardeland R, Peoggeler B, Huether G, Olah A, Nagy G, Csernus V, Kasxaki J, Pan W , Otsuka K, Halberg F. Chronomics reveal and quantify circadian rhythmic melatonin in duodenum of rats. Biomedicine & Pharmocotherapy, 59: S208 - S211, 2005. [full text]

10. Zeman M, Józsa R, Cornélissen G, Stebelova K, Bubenik G, Olah A, Peoggeler B, Huether G, Hardeland R, Nagy G, Czernus V, Pan W , Otsuka K, Halberg F. Chronomics: circadian lead of extrapineal vs. pineal melatonin rhythms with an infradian hypothalamic exploration. Biomedicine & Pharmocotherapy, 59: S212 - S218, 2005. [full text]

11. Poeggeler B, Cornélissen G, Huether G, Hardeland R, Józsa R, Zeman M, Balazova K, Oláh A, Bubenik G, Pan W , Otsuka K, Schwartzkopff O, Halberg F. Chronomics affirm extending scope of lead in phase of duodenal vs pineal circadian melatonin rhythms. Biomedicine & Pharmocotherapy, 59: S219 - S223, 2005. [full text]

Year 2004 full papers:

1. Pan W , Kastin AJ. Why study transport of peptides and proteins at the neurovascular interface. Brain Research Review, 46: 32 - 43, 2004 [full text]

2. Somogyvari-Vigh A, Kastin AJ, Liao J, Zadina JE, Pan W. Endormorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells. Experimental Brain Research, 156: 224 - 230, 2004 [full text]

3. Quinton LJ, Nelson S, Zhang P, Boé DM, Happel KI, Pan W, Bagby GJ. Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment. American Journal of Physiology, 286: L465 - L472, 2004 [full text]

4. Kastin AJ, Akerstrom V, Pan W. Neuregulin-1-beta 1 enters brain and spinal cord by receptor-mediated transport. Journal of Neurochemistry, 88: 965 - 970, 2004 [full text]

5. Pan W, Kastin AJ. Delivery of peptides and proteins across the blood-brain barrier. Current Drug Targets - CNS and Neurological Disorders, 3: 131 - 136, 2004 [full text]

6. Pejovic V, Soskic V, Pan W, Kastin AJ. Brain proteome of mice lacking the receptors for tumor necrosis factor alpha. Proteomics, 4: 1461 - 1464, 2004 [full text]

7. Pan W, Akerstrom V, Zhang J, Pejovic V, Kastin AJ. Modulation of feeding-related peptide /protein signals by the blood-brain barrier. Journal of Neurochemistry, 90: 455 - 461, 2004 [full text]

8. Yu Y, Jawa A , Pan W , Kastin AJ. Effects of peptides, with emphasis on feeding, pain, and behavior. A 5-year (1999-2003) review of publications in Peptides. Peptides, 25: 2257 - 2289, 2004 [full text]

9. Pan W , Kastin AJ, Zankel T, van Kerkhoff P, Terasaki T, Bu G. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. Journal of Cell Science, 117: 5071 - 5078, 2004 [full text]

10. Pan W , Kastin AJ, Pick CG. The staircase test in mice after SCI. GCNN Journal, 1: 32 - 37, 2004 [full text]

11. Kastin AJ. Twenty-five years of peptides. Peptides, 25:315 - 317, 2004 [full text]

Lists of papers can be found in:

· Abba J. Kastin, M.D.

· Weihong Pan, M.D., Ph.D.